Single molecule studies characterize the kinetic mechanism of tetrameric p53 binding to different native response elements
J. P. Suwita, C. K. Voong, E. Ly, J. A. Goodrich, J. F. Kugel
This study uses single molecule fluorescence to analyze p53 tetramer binding dynamics to five native response elements, revealing two kinetically distinct populations and sequence-dependent dissociation rates.
bioRxiv · Jun 1, 2022Biochemistry