Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AML
L. Chen, E. Pronk, C. van Dijk, Y. Bian, J. Feyen, T. van Tienhoven, M. Yildirim, P. Pisterzi, M. de Jong, A. Bastidas, R. Hoogenboezem, C. Wevers, E. Bindels, B. Lowenberg, T. Cupedo, , M. Raaijmakers
The paper uses scRNA-seq to analyze signaling between hematopoietic stem/progenitor cells and their niches in AML, identifying inflammatory niche remodeling as a factor affecting tissue failure and patient outcome.
bioRxiv · May 5, 2023 · PreprintCancer Biology