M. A. Sanders

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

This study uses single-cell DNA sequencing to analyze preleukemic hematopoietic stem cells and finds pervasive positive selection throughout preleukemic evolution, with selective advantages ranging from 9%-24% per year.

Methods for making and observing model lipid droplets

This paper describes methods to create and analyze model lipid droplets (mLDs) to study triglyceride metabolism through biophysical measurements.

Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AML

The paper uses scRNA-seq to analyze signaling between hematopoietic stem/progenitor cells and their niches in AML, identifying inflammatory niche remodeling as a factor affecting tissue failure and patient outcome.

An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

The paper identifies a neutrophil-stromal cell feedback loop in multiple myeloma that promotes BAFF-rich inflammation, persisting after treatment and suggesting dual targeting strategies.

Four-color fluorescence cross-correlation spectroscopy with one laser and one camera

This paper introduces a four-color FCCS method using a single laser and camera to measure diffusion and oligomerization of fluorophores in biological systems.

Immune-mediated tumor control in the 5TGM1 transfer model of multiple myeloma

This study uses a murine model to show that C57Bl/6 mice can control multiple myeloma through IFN-gamma-dependent immune responses, highlighting the model's utility for studying anti-myeloma immunity.

Clonal diversification and histogenesis of malignant germ cell tumours

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

The mutational landscape of normal human endometrial epithelium

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

The landscape of somatic mutation in normal colorectal epithelial cells

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.