Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data
D. Wüstner, A. D. Juhl, J. Egebjerg, S. Werner, J. G. McNally, G. Schneider
The paper uses kinetic modeling of sterol transport data to show that NPC2 deficiency leads to lipid accumulation in LE/LYS intraluminal vesicles, supported by X-ray imaging.
bioRxiv · Jan 28, 2023Biophysics