A mosaic gastruloid model highlights the developmental stage-specific restriction of cell competition in mammalian pre-gastrulation
Joshua D. Frenster, S. Babin, J.B. Josende Garcia, Pablo Casani-Galdon, Pau Pascual-Mas, G. Robertson, J. Garcia Ojalvo, Alfonso Martínez Arias
This study uses mosaic gastruloids to show that cell competition in mammalian embryos is restricted to a specific developmental window and depends on signaling pathways like Wnt and BMP.
bioRxiv · Jan 25, 2025 · PreprintDevelopmental Biology