Alfonso Martínez Arias

This study compares the effects of homemade and commercial N2B27 media on mouse gastruloid development, finding differences in timing, cell number, and gene expression patterns.

This paper introduces a 3D hemogenic gastruloid model to study infant acute myeloid leukemia origins, showing MNX1-driven transformation of erythroid-myeloid progenitors.

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

This study uses mosaic gastruloids to show that cell competition in mammalian embryos is restricted to a specific developmental window and depends on signaling pathways like Wnt and BMP.

This study shows that Nodal and Wnt signalling act antagonistically during mammalian gastrulation, with Nodal promoting anterior structures and Wnt driving posterior development.

This study investigates how size affects morphogenesis and transcriptional profiles in mouse gastruloids, revealing size-dependent changes in axial elongation and tissue composition.

This study shows how cell-state transitions and collective movement create an endoderm-like region in mouse gastruloids without requiring epithelial-to-mesenchymal transition.

The paper introduces VASA-seq, a method for total single-cell RNA-seq in mice, revealing non-coding RNA expression and alternative splicing during development.

This study develops EpiTS embryoids, which mimic post-implantation development in vitro by combining ESC and TSC aggregates to model gastrulation and axial morphogenesis.

The paper shows that zebrafish embryos can break symmetry autonomously when isolated, indicating that extra-embryonic tissues are not strictly required for early patterning.

The paper analyzes in vitro NMPs derived from ESCs and EpiSCs, finding that EpiSC-derived NMPs more closely resemble in vivo NMPs and contain a node-like population maintaining T expression.

The paper identifies a multipotent progenitor population derived from Epiblast Stem Cells that self-renew and express a gene signature similar to embryonic NMPs.