Removal of the C6 vaccinia virus interferon-β inhibitor in the hepatitis C vaccine candidate MVA-HCV elicited in mice high immunogenicity in spite of reduced host gene expression
M. Q. Marin, P. Perez, C. E. Gomez, C. O. S. Sorzano, M. Esteban, J. Garcia-Arriaza
The paper describes a modified HCV vaccine candidate, MVA-HCV ΔC6L, which lacks an IFN-β inhibitor and shows strong immunogenicity in mice despite reduced host gene expression.
bioRxiv · May 25, 2018Immunology