C. O. S. Sorzano

AlignPCA-2D improves 2D classification in cryo-EM by using PCA-reduced Euclidean vector alignment, achieving competitive accuracy with lower computational cost.

This study shows growth hormone remodels mitochondrial structure and promotes metabolic reprogramming in inflammatory macrophages.

This paper introduces FSC-Q, a method to assess local map-to-model fit in cryoEM by comparing local FSC values from full and half maps, helping to avoid overfitting.

This paper introduces a new automatic method for sharpening cryo-EM maps based on local resolution, improving map quality and interpretability.

ENRICH improves 3D map quality from small, heterogeneous cryo-EM datasets by merging particles across conformations using optical flow.

The paper describes a modified HCV vaccine candidate, MVA-HCV ΔC6L, which lacks an IFN-β inhibitor and shows strong immunogenicity in mice despite reduced host gene expression.