Skeletal Phenotype and Mechanisms of Bone Loss in Winnie Mice as a Model for Inflammatory Bowel Disease
A. Al Saedi, S. Sharma, E. Bani Hassan, L. Chen, A. Ghasem-Zadeh, M. Hassanzadeganroudsari, J. Gooi, R. Stavely, E. Rajamaran, D. Miao, K. Nurgali, G. Duque
This study investigates bone loss mechanisms in Winnie mice, a model for IBD, finding elevated gut-derived serotonin inhibits osteoblastogenesis through molecular pathway interactions.
bioRxiv · Sep 28, 2020 · PreprintPhysiology