Molecular characterization of response to etrolizumab and anti-TNF reveals treatment resistance in ulcerative colitis is associated with the abundance of residual neutrophil subsets and inflammatory fibroblast populations
S. Toghi Eshghi, J. M. Gubatan, P. Mazrooei, L. Quintanilla, A. Nguyen, A. Au-Yeung, D. R. Holman, C. Takahashi, C. Schiffman, W. O'Gorman, M. Keir, S. Ramanujan, S. Rogalla, J. Hackney, J. M. McBride
The paper identifies treatment resistance in ulcerative colitis linked to residual neutrophil subsets and inflammatory fibroblasts using single-cell analysis of biopsy data.
bioRxiv · Jul 2, 2024 · PreprintImmunology