A. Nguyen

ORF48 is required for optimal lytic replication of Kaposis Sarcoma-Associated Herpesvirus

This study shows ORF48 is essential for KSHV lytic replication by inhibiting the cGAS-STING pathway and blocking innate immune signaling.

Widespread parasite infections in living resident killer whales in the Northeast Pacific Ocean

The paper examines parasite infections in killer whales, finding widespread Anisakis spp. infections across populations without correlation to body condition.

Far-red and sensitive sensor for monitoring real-time H2O2 dynamics with subcellular resolution and inmulti-parametric imaging applications.

This paper introduces a new fluorescent sensor, oROS-HT, for real-time H2O2 monitoring with subcellular resolution and multi-parametric imaging capabilities.

Variability in drought gene expression datasets highlight the need for community standardization

This study analyzes drought gene expression datasets and finds they are inconsistent, proposing classifiers to detect drought stress and advocating for standardized protocols.

Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid

This study investigates the assembly of SARS-CoV-2 nucleocapsid protein with nucleic acids using biophysical techniques and mutant proteins, revealing key interaction motifs and stabilization mechanisms.

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

The protein phosphatase-2A subunit PR130 is linked to cytotoxic protein aggregate formation in mesenchymal pancreatic ductal adenocarcinoma cells

This study shows that mesenchymal pancreatic ductal adenocarcinoma cells depend on the PP2A subunit PR130, and its inhibition by phendione leads to apoptosis and protein aggregate formation.

Molecular Basis of Cell Membrane Adaptation in Daptomycin-Resistant Enterococcus faecalis

This study identifies the role of cardiolipin synthase and the LiaFSR system in daptomycin resistance by redistributing anionic phospholipids in Enterococcus faecalis.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Hypogonadal (Gnrh1hpg) mice reveal niche-specific influence of reproductive axis and sex on intestinal microbial communities

This study uses hypogonadal mice to show sex and reproductive axis effects on intestinal microbial communities, with sex chromosomes also playing a role, and highlights limitations of fecal samples in reflecting small intestine diversity.

Impact of Common Modifications on the Antigenic Profile and Glycosylation of Membrane-Expressed HIV-1 Envelope Glycoprotein.

This study evaluates how stabilizing mutations in HIV-1 Env affect trimer stability, antigenicity, and glycosylation when expressed on membrane-expressed VLPs, finding some mutations reduce neutralizing antibody binding and alter glycan processing.

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Functional and genetic adaptations contributing to Enterococcus faecalis persistence in the female urinary tract

This study identifies genetic adaptations in Enterococcus faecalis strains isolated from the urinary tract of postmenopausal women that may contribute to their persistence in the urinary tract.

Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer

This study identifies dynein-powered locomotion as a complementary mechanism to actomyosin-driven movement in metastatic breast cancer cells, showing its necessity and sufficiency in 3D migration.

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

Cell dichotomous role of STING in pulmonary hypertension

This study investigates the role of STING in pulmonary hypertension, finding that STING overactivation contributes to disease while global deficiency protects against it, with distinct cellular roles in smooth muscle and myeloid cells.

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

Cross-species predictive modeling reveals conserved drought responses between maize and sorghum

This paper develops a predictive model to identify drought responses in sorghum and applies it to maize, finding conserved drought response genes across species.

Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

This study identifies the molecular mechanism of autophagy initiation by revealing the role of metamorphic proteins ATG13-101 in forming the autophagy initiation supercomplex.

Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes

This study identifies Rab38 as a physiological regulator of LRRK2 function in melanocytes, showing it enhances LRRK2 membrane recruitment and substrate phosphorylation.

Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration

This study identifies compressive stress as a driver of unjamming transitions in breast cancer cell migration by showing that cell-cell adhesion, not epithelial-mesenchymal transition, mediates these changes.

Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

imageseg: an R package for deep learning-based image segmentation

The paper introduces an R package for deep learning-based image segmentation, demonstrating its utility in ecological applications with high accuracy models for forest structure.

Mosquito excreta reveals circulation of West Nile virus and its underlying ecosystem

The paper identifies West Nile Virus circulation in Camargue using mosquito excreta-based xenomonitoring and reveals ecological networks of arbovirus transmission.

Recurrent urinary tract infection and estrogen shape the taxonomic ecology and functional potential of the postmenopausal urobiome

This study investigates how recurrent UTI and estrogen influence the urobiome's taxonomic and functional features in postmenopausal women using metagenomic and metabolomic analyses.

Alterations in gut microbiome composition and function in irritable bowel syndrome and increased probiotic abundance with daily supplementation

This study identifies microbiome differences between healthy individuals and IBS patients and shows probiotic supplementation improves microbiome scores in IBS.

Independently paced calcium oscillations in progenitor and differentiated cells in an ex vivo epithelial organ

The paper examines calcium dynamics in different cell types of the Drosophila intestine, showing that calcium oscillations are independent between progenitor and differentiated cells.