Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations
Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar M. Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim, Kara Battaglia, J. Herrera, Gianna Garifo-MacPartland, Dianne Newcombe, Latoya Okundaye, Heather Paglia, Julia A. Paxson
This study shows that age-related decline in canine lung mesenchymal stromal cell proliferation is linked to quiescence rather than senescence, with minimal transcriptomic changes.
PLoS ONE · Jul 23, 2025Peer-reviewedDevelopmental Biology