Author

M. Okhovat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

L. Carbone· 3 shared B. Davis· 2 shared K. Nevonen· 2 shared L. Harshman· 2 shared N. Ahituv· 2 shared S. Ward· 2 shared A. C. Lima· 1 shared A. Foley· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersEvolutionary Biology

L. Carbone

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Author profile →

3 papers

Recent·Most cited

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

M. Okhovat, J. VanCampen, A. C. Lima, K. Nevonen, C. E. Layman, S. Ward, J. Herrera, A. M. Stendahl, R. Yang, L. Harshman, W. Li, R. R. Sheng, Y. Mao, L. Fedorov, B. Ndjamen, , L. Carbone

The paper analyzes TAD boundaries across species to show evolutionary conservation and functional significance, finding ultraconserved boundaries have stronger insulation and CTCF binding.

bioRxiv · Mar 7, 2023Evolutionary Biology

Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome

M. Okhovat, K. A. Nevonen, B. Davis, P. Michener, S. Ward, M. Milhaven, L. Harshman, A. Sohota, J. D. Fernandes, S. R. Salama, R. J. O'Neill, N. Ahituv, K. R. Veeramah, L. Carbone

This study investigates the role of the lineage-specific LAVA retrotransposon in gibbon gene regulation, finding it overlaps with enhancer chromatin states and is associated with gene expression and selection.

bioRxiv · Apr 6, 2020Evolutionary Biology

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

T. P. Braun, M. Okhovat, C. Coblentz, S. A. Carratt, A. Foley, Z. Schonrock, K. Nevonen, B. Davis, B. Garcia, D. LaTocha, B. R. Weeder, M. R. Grzadkowski, J. C. Estabrook, H. G. Manning, K. Watanabe-Smith, , J. E. Maxson

The paper identifies mutation synergy between CSF3R and CEBPA in AML, showing their interaction at myeloid lineage enhancers and the requirement of CEBPA mutations as an initial event.

bioRxiv · May 15, 2019Cancer Biology