Mechanistic Insights into ASO-RNA Complexation: Advancing Antisense Oligonucleotide Design Strategies.
J. Horberg, A. Carlesso, A. Reymer
This study uses molecular dynamics simulations to show that ASO-mRNA complex stability depends on ASO length, triple base pairs, and hairpin loop accessibility, offering insights for ASO design.
bioRxiv · Apr 18, 2024Biophysics