DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination
J. J. Crowe, X. Wang, Z. Shao, B. J. Lee, V. Estes, S. Zha
This study shows that DNA-PKcs phosphorylation at T2609 cluster promotes cNHEJ repair pathway choice during CSR, as loss of this phosphorylation increases chromosomal translocation and alternative end-joining.
bioRxiv · Apr 23, 2020Immunology