Author

J. J. Holst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. J. Wewer Albrechtsen· 3 shared B. Hartmann· 2 shared C. Oerskov· 2 shared J. Pedersen· 2 shared K. D. Galsgaard· 2 shared S. L. Jepsen· 2 shared A. Billeschou Bomholt· 1 shared C. B. Christiansen· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPhysiology

N. J. Wewer Albrechtsen

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Author profile →

4 papers

Recent·Most cited

Inhibition of dipeptidyl peptidase 4 allows accurate measurement of GLP-1 secretion in mice

M. M. Smits, K. D. Galsgaard, S. L. Jepsen, N. Wewer Albrechtsen, B. Hartmann, J. J. Holst

This study shows that inhibiting DPP-4 and NEP in mice improves the detection of intact GLP-1 using commercial ELISA kits, but may affect metabolic outcomes.

bioRxiv · Oct 19, 2023 · PreprintPhysiology

Evaluation of Commercially Available Glucagon Receptor Antibodies and Glucagon Receptor Expression

A. Billeschou Bomholt, C. Dall Johansen, S. A. S. Kjeldsen, K. Douglas Galsgaard, J. Bager Christensen, M. Winther-Soerensen, R. Serizawa, M. Hornum, E. Porrini, J. Pedersen, C. Oerskov, L. L. Gluud, C. Mehlin Soerensen, J. J. Holst, R. Albrechtsen, N. J. Wewer Albrechtsen

This study evaluates commercially available glucagon receptor antibodies and identifies a specific antibody for GCGR localization, confirming liver and kidney as primary glucagon targets.

bioRxiv · Dec 21, 2021Physiology

Alanine, arginine, and proline but not glutamine are the feed-back regulators in the liver-alpha cell axis in mice

K. D. Galsgaard, S. L. Jepsen, S. Kjeldsen, J. Pedersen, N. J. Wewer Albrechtsen, J. J. Holst

The paper identifies alanine, arginine, and proline as amino acids that stimulate glucagon secretion in mice, showing their metabolism depends on glucagon receptor signaling.

bioRxiv · Oct 15, 2019 · PreprintPhysiology

Secretin release after Roux-en-Y Gastric Bypass reveals a population of glucose-sensitive S-cells in distal small intestine

I. M. Modvig, D. B. Andersen, K. V. Grunddal, R. E. Kuhre, C. Martinussen, C. B. Christiansen, C. Oerskov, P. Larraufie, R. Kay, F. Reimann, F. Gribble, B. Hartmann, K. Bojsen-Moeller, S. Madsbad, N. J. Wewer Albrechtsen, J. J. Holst

This study shows that RYGB surgery increases postprandial secretin levels, identifies glucose-sensitive S-cells in the distal small intestine, and demonstrates secretin's effects on glucose regulation.

bioRxiv · Oct 2, 2019Physiology