Convergent Hybrid Phase Ligation Strategy for Efficient Total Synthesis of Large Proteins Demonstrated for 212-residue Linker Histone H1.2
Z. Z. Hong, R. R. Yu, X. Zhang, A. M. Webb, N. L. Burge, M. G. Poirier, J. J. Ottesen
The paper develops a convergent hybrid phase ligation strategy for synthesizing large proteins, demonstrating its effectiveness with the 212-residue histone H1.2.
bioRxiv · Jun 6, 2019Biochemistry