At the Intersection Between SARS-CoV-2, Macrophages and the Adaptive Immune Response: A Key Role for Antibody-Dependent Pathogenesis But Not Enhancement of Infection in COVID-19
J. K. DeMarco, W. Severson, D. DeMarco, G. Pogue, J. D. Gabbard, K. E. Palmer
This study investigates immune dysregulation in COVID-19, showing macrophage activation by non-neutralizing antibodies and ACE2 induction leads to macrophage death and downstream epithelial cell susceptibility.
bioRxiv · Feb 22, 2021 · PreprintImmunology