MX2 viral substrate breadth and inhibitory activity are regulated by protein phosphorylation
G. Betancor, M. E. M. Bangham, J. K. Jeon, K. Sha, S. Lynham, J. M. Jimenez Guardeno, M. H. Malim
This paper identifies key phosphorylation sites in MX2 that regulate its antiviral activity and substrate specificity, showing that hypermorphic mutants can inhibit HIV-1 and resistant retroviruses.
bioRxiv · Jan 24, 2022Microbiology