Defining the mechanisms of action and resistance to the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain models
M. Phadke, J. Li, Z. Chen, P. C. Rodriguez, J. K. Mandula, L. Karapetyan, P. A. Forsyth, A. Chen, K. S. Smalley
This study investigates the mechanisms of action and resistance of anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma models, finding differential effects on CD4+ T cell polarization and CD8+ T cell function.
bioRxiv · Apr 14, 2023 · PreprintImmunology