Author

P. A. Forsyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Alhaddad· 2 shared I. Smalley· 2 shared M. L. Khaled· 2 shared O. E. Ospina· 2 shared Y. Ren· 2 shared Z. Chen· 2 shared A. Chen· 1 shared B. Evernden· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

H. Alhaddad

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

M. L. Khaled, Y. Ren, R. Kundalia, H. Alhaddad, Z. Chen, G. C. Wallace, B. Evernden, O. E. Ospina, M. Hall, M. Liu, L. N. F. Darville, V. Izumi, Y. A. Chen, S. Pilon-Thomas, P. A. Stewart, , I. Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

bioRxiv · Dec 18, 2023 · PreprintCancer Biology

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

H. Alhaddad, O. E. Ospina, M. L. Khaled, Y. Ren, P. A. Forsyth, Y. Pina, R. Macaulay, V. Law, K. Y. Tsai, W. D. Cress, B. Fridley, I. Smalley

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

bioRxiv · Dec 18, 2023Cancer Biology

Defining the mechanisms of action and resistance to the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain models

M. Phadke, J. Li, Z. Chen, P. C. Rodriguez, J. K. Mandula, L. Karapetyan, P. A. Forsyth, A. Chen, K. S. Smalley

This study investigates the mechanisms of action and resistance of anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma models, finding differential effects on CD4+ T cell polarization and CD8+ T cell function.

bioRxiv · Apr 14, 2023 · PreprintImmunology