Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases
J. K. Yi, R. Xu, L. M. Obeid, Y. A. Hannun, M. V. Airola, C. Mao
This study investigates the catalytic mechanism of ACER3, identifying key residues and demonstrating its Zn2+-dependent activity similar to other Zn-based amidases.
bioRxiv · Oct 13, 2018Biochemistry