Axonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticity
M. Bell-Simons, Sarah Buchholz, J. Klimek, Hans Zempel
This study identifies the PRR2 domain as essential for axonal Tau sorting and reveals isoform-specific interactions that may influence synaptic plasticity and Alzheimer's disease pathology.
bioRxiv · Jun 28, 2024 · PreprintNeuroscience