Hans Zempel

The paper identifies de novo variants in PCBP1 causing neurodevelopmental disorders, showing impaired dendritic arborization and increased exon skipping in T cells.

This study shows that TTLL6 disrupts microtubule dynamics and that LDC10 inhibits TTLL activity and reverses TTLL6's effects.

This study shows that knocking down TTLL1 reduces Aβ-induced TAU pathology and microtubule dysfunction in human iPSC-derived neurons.

This study identifies the PRR2 domain as essential for axonal Tau sorting and reveals isoform-specific interactions that may influence synaptic plasticity and Alzheimer's disease pathology.

This study shows that SH-SY5Y-derived neurons can efficiently sort axonal TAU, requiring the C-terminus but not ANKG or TRIM46 at the AIS.

This study examines the subcellular localization and effects of different human TAU isoforms on cell size and microtubule dynamics in neuroblastoma cells.