The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteins
K. R. McCarthy, J. L. Timpona, S. Jenni, V. Brusic, W. E. Johnson, S. P. J. WHELAN, L. R. Robinson-McCarthy
The paper identifies EnvP(b)1, an ancient retroviral envelope gene expressed in human tissues, and shows its structural similarity to modern leukemia virus Envs, suggesting a conserved scaffold for receptor binding evolution.
bioRxiv · Apr 22, 2020 · PreprintMicrobiology