Author

L. R. Robinson-McCarthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:multiple species· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

K. R. McCarthy· 6 shared A. Watanabe· 2 shared G. Kelsoe· 2 shared M. Kuraoka· 2 shared S. Nambulli· 2 shared S. P. J. WHELAN· 2 shared W. P. Duprex· 2 shared A. P. Moseman· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersMicrobiology

K. R. McCarthy

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Author profile →

6 papers

Recent·Most cited

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

H. C. Simmons, J. Finney, R. Kotaki, Y. Adachi, A. P. Moseman, A. Watanabe, S. Song, L. R. Robinson-McCarthy, V. Le Sage, M. Kuraoka, E. A. Moseman, G. Kelsoe, Y. Takahashi, K. R. McCarthy

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

bioRxiv · Dec 13, 2023Microbiology

Deletion disrupts a conserved antibody epitope in a SARS-CoV-2 variant of concern

L. L. Rennick, L. R. Robinson-McCarthy, S. Nambulli, W. P. Duprex, K. R. McCarthy

The paper identifies a SARS-CoV-2 variant with a deletion in the RBD that disrupts a conserved antibody epitope across sarbecoviruses.

bioRxiv · Mar 5, 2021 · PreprintMicrobiology

A prevalent focused human antibody response to the influenza hemagglutinin head interface

K. R. McCarthy, J. Lee, A. Watanabe, M. Kuraoka, L. R. Robinson-McCarthy, G. Georgiou, G. Kelsoe, S. Harrison

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

bioRxiv · Dec 28, 2020Immunology

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

K. R. McCarthy, L. J. Rennick, S. Nambulli, L. R. Robinson-McCarthy, W. G. Bain, G. Haidar, W. P. Duprex

The paper identifies recurrent deletions in the SARS-CoV-2 spike glycoprotein that drive antibody escape by altering epitopes and accelerating antigenic evolution.

bioRxiv · Nov 19, 2020Microbiology

The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteins

K. R. McCarthy, J. L. Timpona, S. Jenni, V. Brusic, W. E. Johnson, S. P. J. WHELAN, L. R. Robinson-McCarthy

The paper identifies EnvP(b)1, an ancient retroviral envelope gene expressed in human tissues, and shows its structural similarity to modern leukemia virus Envs, suggesting a conserved scaffold for receptor binding evolution.

bioRxiv · Apr 22, 2020 · PreprintMicrobiology

Reconstruction of the cell entry pathway of an extinct virus

L. R. Robinson-McCarthy, K. R. McCarthy, M. Raaben, S. Piccinotti, J. Nieuwenhuis, S. H. Stubbs, M. J. G. Bakker, S. P. J. Whelan

This study identifies heparan sulfate as critical for HERV-K virus entry and defines key steps in its infectious pathway.

bioRxiv · May 25, 2018Microbiology