Extending ligand efficacy indices with compound pharmacokinetic characteristics towards holistic Compound Quality Scores
C. S. Tautermann, J. M. Borghardt, R. Pfau, M. Zentgraf, N. Weskamp, A. Sauer
This paper introduces Compound Quality Scores that integrate pharmacokinetic parameters with potency to prioritize compounds for synthesis and testing.
bioRxiv · Aug 30, 2023Pharmacology & Toxicology