Author

C. S. Tautermann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. C. W. Pike· 1 shared A. Pautsch· 1 shared A. Quigley· 1 shared A. Sauer· 1 shared D. B. Sauer· 1 shared E. P. Carpenter· 1 shared G. Chi· 1 shared G. Schnapp· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. C. W. Pike

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2 papers

Recent·Most cited

Structural basis of the mechanism and inhibition of a human ceramide synthase

T. C. Pascoa, A. C. W. Pike, C. S. Tautermann, G. Chi, M. Traub, A. Quigley, R. Chalk, S. Stefanic, S. Thamm, A. Pautsch, E. P. Carpenter, G. Schnapp, D. B. Sauer

This study determines the structural mechanism of CerS6, a ceramide synthase, using cryo-EM and biochemical analysis, revealing a ping-pong reaction mechanism and insights into fumonisin B1 inhibition.

bioRxiv · Dec 2, 2023Biochemistry

Extending ligand efficacy indices with compound pharmacokinetic characteristics towards holistic Compound Quality Scores

C. S. Tautermann, J. M. Borghardt, R. Pfau, M. Zentgraf, N. Weskamp, A. Sauer

This paper introduces Compound Quality Scores that integrate pharmacokinetic parameters with potency to prioritize compounds for synthesis and testing.

bioRxiv · Aug 30, 2023Pharmacology & Toxicology