Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
J. A. Amrhein, L. M. Berger, D.-I. Balourdas, A. C. Joerger, A. Menge, A. Kraemer, J. M. Frischkorn, B.-T. Berger, L. Elson, A. Kaiser, M. Schubert-Zsilavecz, S. Mueller, S. Knapp, T. Hanke
The paper designs and synthesizes a macrocyclic inhibitor, JA310, that selectively targets MST3 with high potency and kinome-wide selectivity.
bioRxiv · Oct 20, 2023Biochemistry