Plexin-Bs enhance their GAP activity with a novel activation switch loop
Z. LI, J. M. Greven, S. Kim, L. Tamagnone, M. Buck
The paper identifies a novel activation switch loop in Plexin-B1 that enhances its GAP activity towards Rap1b through a cooperative mechanism involving conformational changes.
bioRxiv · May 24, 2020Biophysics