Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study
K. Kahraman, S. A. Robson, O. Gocenler, C. M. Yenici, C. D. Tozkoparan, J. M. Klein, V. Dötsch, E. S. Elgin, A. L. Haas, J. J. Ziarek, C. Dag
This study uses SAXS and NMR to show UbcH8 exists in a concentration-dependent monomer-dimer equilibrium with dimerization affecting E1 and E3 interfaces.
bioRxiv · Apr 13, 2023Biochemistry