Author

S. A. ROBSON

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Assay:protein structure· 2 Approach:biophysical modeling· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. J. Ziarek· 6 shared A. Inoue· 3 shared F. Bumbak· 3 shared H. Wu· 3 shared C. Dag· 2 shared D. J. Scott· 2 shared F. Yan· 2 shared J. C. Paniagua· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersBiophysics

J. J. Ziarek

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6 papers

Recent·Most cited

Insights on the GPCR helix 8 solution structure and orientation using a neurotensin receptor 1 peptide

J. B. Bower, S. A. Robson, J. J. Ziarek

This study investigates the structural stability and orientation of the neurotensin receptor 1 H8-Ctail using NMR in detergent and lipid environments, revealing its sensitivity to membrane conditions.

bioRxiv · Jan 31, 2024 · PreprintBiophysics

Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study

K. Kahraman, S. A. Robson, O. Gocenler, C. M. Yenici, C. D. Tozkoparan, J. M. Klein, V. Dötsch, E. S. Elgin, A. L. Haas, J. J. Ziarek, C. Dag

This study uses SAXS and NMR to show UbcH8 exists in a concentration-dependent monomer-dimer equilibrium with dimerization affecting E1 and E3 interfaces.

bioRxiv · Apr 13, 2023Biochemistry

The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias

F. Bumbak, A. Inoue, M. Pons, J. C. Paniagua, F. Yan, H. Wu, S. A. ROBSON, R. A. D. Bathgate, D. J. Scott, P. R. Gooley, J. J. Ziarek

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

bioRxiv · Nov 25, 2022Biochemistry

Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis

F. Bumbak, M. Pons, A. Inoue, J. C. Paniagua, F. Yan, H. Wu, S. A. ROBSON, R. Bathgate, D. J. Scott, P. R. Gooley, J. J. Ziarek

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

bioRxiv · Aug 9, 2022Biophysics

The Effect of Ligands and Transducers on the Neurotensin Recep-tor 1 (NTS1) Conformational Ensemble

A. D. Dixon, A. Inoue, S. A. ROBSON, K. Culhane, J. Trinidad, S. Sivaramakrishnan, F. Bumbak, J. J. Ziarek

This study uses 19F-NMR to show ligands and transducers modulate NTS1 conformational substates, revealing dynamic behavior not captured by static structures.

bioRxiv · Dec 8, 2021Biophysics

TRACT revisited: an algebraic solution for determining overall rotational correlation times from cross-correlated relaxation rates

S. A. ROBSON, C. Dag, H. Wu, J. J. Ziarek

The paper develops algebraic solutions to improve the accuracy of rotational correlation time estimation using TRACT experiments by addressing limitations in existing methods.

bioRxiv · Jan 16, 2021Biophysics