Short tandem repeats bind transcription factors to tune eukaryotic gene expression
C. A. Horton, A. M. Alexandari, M. G. B. Hayes, E. Marklund, J. M. Schaepe, A. K. Aditham, N. Shah, A. A. Shrikumar, A. Afek, W. J. Greenleaf, R. Gordan, J. Zeitlinger, A. Kundaje, P. M. Fordyce
This study shows STRs modulate TF-DNA interactions by altering binding affinities and on rates, impacting gene expression through increased TF density near target sites.
bioRxiv · May 24, 2022Biophysics