Author

J. Zeitlinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. A. Shrikumar· 1 shared A. Afek· 1 shared A. K. Aditham· 1 shared A. Kundaje· 1 shared A. M. Alexandari· 1 shared C. A. Horton· 1 shared E. Marklund· 1 shared G. R. Rice· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

A. A. Shrikumar

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2 papers

Recent·Most cited

Gene regulatory network co-option is sufficient to induce a morphological novelty in Drosophila

G. R. Rice, T. Gaitan-Escudero, K. Charles-Obi, J. Zeitlinger, M. Rebeiz

This study shows that co-opting the trichome genetic network in Drosophila can induce large apical projections on the phallus, demonstrating the flexibility of gene regulatory networks in evolving new morphologies.

bioRxiv · Mar 22, 2024Evolutionary Biology

Short tandem repeats bind transcription factors to tune eukaryotic gene expression

C. A. Horton, A. M. Alexandari, M. G. B. Hayes, E. Marklund, J. M. Schaepe, A. K. Aditham, N. Shah, A. A. Shrikumar, A. Afek, W. J. Greenleaf, R. Gordan, J. Zeitlinger, A. Kundaje, P. M. Fordyce

This study shows STRs modulate TF-DNA interactions by altering binding affinities and on rates, impacting gene expression through increased TF density near target sites.

bioRxiv · May 24, 2022Biophysics