SARS-CoV-2 nsp3-4 suffice to form a pore shaping replication organelles
L. Zimmermann, X. Zhao, J. Makroczyova, M. Wachsmuth-Melm, V. Prasad, R. Bartenschlager, P. Chlanda
The paper identifies nsp3-4 as the minimal components forming a DMV-spanning pore in SARS-CoV-2 replication organelles, critical for membrane curvature and DMV formation.
bioRxiv · Oct 21, 2022 · PreprintMicrobiology