Mistargeting of hydrophobic mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes
C. E. Dewar, S. Oeljeklaus, J. Mani, W. W. D. Mühlhäuser, B. Warscheid, A. Schneider
This study shows that ablation of ATOM69 in Trypanosoma brucei triggers a nucleus-mediated quality control pathway leading to proteasomal degradation of mislocalized mitochondrial proteins.
bioRxiv · Aug 13, 2021 · PreprintBiochemistry