A. Schneider

T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

Intermembrane space-localized twin Cx9C motif-containing TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes

The paper identifies TbTim15 as an essential subunit of the trypanosome TIM complex, showing it mediates import of both presequence-containing and mitochondrial carrier proteins.

Evolutionary repurposing of trypanosomal Pam18 and Pam16 reveals a new regulatory circuit for mitochondrial genome replication

This study shows that TbPam16 and TbPam18 in Trypanosoma brucei regulate maxicircle replication in mitochondria through a novel regulatory circuit involving MaRF11 and proteasomal control.

A single-cell atlas of the aging murine ovary

This study creates a single-cell RNA sequencing atlas of aging mouse ovaries, identifying immune cell expansion, collagenase pathway downregulation, and stress/fibrotic signaling in follicular cells.

A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes

This study identifies a trypanosome Msp1-containing complex that removes orphaned mitochondrial outer membrane proteins through proteasomal digestion.

Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

This study uses cryo-electron tomography to analyze the tripartite attachment complex in Trypanosoma brucei, revealing the structural dynamics of the complex during kDNA segregation.

SUMO interacting motif (SIM) of S100A1 is critical for S100A1 post-translational protein stability

This study identifies a SUMO interacting motif in S100A1 that regulates its post-translational stability through SUMO-mediated interactions.

The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes

This study shows that TbMba1 is essential for oxidative phosphorylation in procyclic trypanosomes but not in bloodstream forms, and identifies its role in Cox complex biogenesis.

Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized pyruvate.

This paper introduces a model-free method to quantify cerebral metabolism using hyperpolarized pyruvate MRI and demonstrates its application in pre-clinical stroke and healthy human brain studies.

Increasing proteome depth while maintaining quantitative precision in short gradient data-independent acquisition proteomics

This paper shows that reducing data points per peak in short gradient DIA-MS increases proteome depth while maintaining quantitative precision.

Immunity priming uncouples the growth-defense tradeoff in tomato

This study shows that immunity priming in tomato can uncouple the growth-defense tradeoff, allowing for disease resistance without compromising growth.

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

Perchlorate-Specific Proteomic Stress Responses of Debaryomyces hansenii Could Enable Microbial Survival in Martian Brines

This study identifies perchlorate-specific proteomic stress responses in Debaryomyces hansenii, revealing mechanisms that may enable microbial survival in Martian brines.

The mitochondrial genome segregation system of T. brucei: Single p197 molecules connect the basal body with the outer membrane

This paper identifies p197 as a key protein bridging the basal body and outer membrane in T. brucei, showing its three domains are essential for mitochondrial DNA segregation.

Floating EMG Sensors and Stimulators Wirelessly Powered and Operated by Volume Conduction for Networked Neuroprosthetics

This paper demonstrates wireless EMG sensors and stimulators powered and operated via volume conduction, enabling flexible, distributed neuroprosthetics.

Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade

The paper identifies plasma proteomic biomarkers that predict non-response to PD1 blockade in melanoma patients and links them to tumor microenvironment biology.

p166 links membrane and intramitochondrial modules of the trypanosomal tripartite attachment complex

This paper identifies p166 as the first inner mitochondrial membrane subunit of the tripartite attachment complex (TAC) in Trypanosoma brucei, showing it connects the kDNA, inner membrane, and outer membrane modules.

CaMK1D signaling in AgRP neurons promotes ghrelin-mediated food intake

This paper identifies CaMK1D as a key mediator of ghrelin-induced food intake in AgRP neurons, showing its role in promoting orexigenic neuropeptide expression and obesity resistance.

Characterisation of a highly diverged mitochondrial ATP synthase peripheral stalk subunit b in Trypanosoma brucei

The paper identifies a 17 kDa mitochondrial protein in Trypanosoma brucei essential for growth and oxidative phosphorylation, showing structural similarity to subunit b of other species.

Mistargeting of hydrophobic mitochondrial proteins activates a nucleus-mediated posttranscriptional quality control pathway in trypanosomes

This study shows that ablation of ATOM69 in Trypanosoma brucei triggers a nucleus-mediated quality control pathway leading to proteasomal degradation of mislocalized mitochondrial proteins.

The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei

This study identifies the TbEMC complex in Trypanosoma brucei, showing it localizes to the mitochondrial-ER interface and modulates phospholipid biosynthesis.

Human immunocompetent Choroid-on-Chip: a novel tool for studying ocular effects of biological drugs

The paper develops a human immunocompetent Choroid-on-Chip model to study ocular effects of biological drugs and assess immunotoxicity.

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

Role of bradykinin type 2 receptors in human sweat secretion: translational evidence does not support a functional relationship

This study tests if bradykinin type 2 receptors affect human sweat secretion using physiological and pharmacological methods, finding no effect of B2R antagonism on sweat rate.

Unbiased antimicrobial resistance detection from clinical bacterial isolates using proteomics

This study presents an unbiased proteomics workflow for detecting bacterial species and antimicrobial resistance proteins from clinical isolates in under 4 hours with high sensitivity and specificity.

Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images

This paper develops a deep-learning method to denoise and reconstruct SR-SIM images, improving image quality and robustness across varying noise levels and microscope settings.

Evaluation of MALDI-ToF Mass Spectrometry for Rapid Detection of Cereulide from Bacillus cereus Cultures

This study evaluates MALDI-ToF MS for detecting cereulide in B. cereus cultures, proposing a workflow that enables rapid and sensitive identification of the toxin using standard equipment.

DNA damage and macrophage infiltration in the ovaries of the long-lived GH deficient Ames Dwarf and the short-lived bGH transgenic mice

This study compares DNA damage, macrophage infiltration, and granulosa cell numbers in GH-deficient and GH-overexpressing mice to assess GH's role in ovarian health.

Identification of Microorganisms by Liquid Chromatography-Mass Spectrometry (LC-MS1) and in silico Peptide Mass Data

This study presents a rapid, accurate, and automatable method for microbial identification using LC-MS1 data and an in silico peptide mass library.

Surface LSP1 is a phenotypic marker distinguishing human classical versus monocyte-derived dendritic cells