Identification of a discrete neuronal circuit that relays insulin signaling into the brain to regulate glucose homeostasis
M. El Mehdi, S. Takhlidjt, M. Devere, A. Arabo, M.-A. Le Solliec, J. Maucotel, A. Benani, E. Nedelec, C. Duparc, B. Lefranc, J. Leprince, Y. Anouar, G. Prevost, N. Chartrel, M. PICOT
This study identifies a neuronal circuit involving 26RFa and GPR103 that mediates insulin's central regulation of glucose homeostasis by enhancing peripheral insulin production.
bioRxiv · Sep 13, 2021 · PreprintPhysiology