Targeted lipid A modification of Shigella vaccine strains reduced endotoxicity without compromising immunogenicity or invasiveness
M. E. Sherman, J. Michalski, S. Das, H. Yang, S. Barnoy, L. Chandrasekaran, M. Venkatesan, R. K. Ernst
This study modifies Shigella lipid A to reduce endotoxicity while maintaining immunogenicity and invasiveness.
bioRxiv · Aug 24, 2023 · PreprintMicrobiology