Author

J. Moriano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

C. Boeckx· 5 shared A. Andirko· 3 shared A. Vitriolo· 2 shared G. Testa· 2 shared D. Grinberg· 1 shared M. Kuhlwilm· 1 shared N. Martinez-Gil· 1 shared O. Leonardi· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersEvolutionary Biology

C. Boeckx

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5 papers

Recent·Most cited

A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution

J. Moriano, O. Leonardi, A. Vitriolo, G. Testa, C. Boeckx

The paper identifies a cholesterol metabolic program in outer radial glia regulated by KLF6 and links it to human brain evolution through integrative analysis of single-cell data and paleogenomic insights.

bioRxiv · Jun 23, 2023Evolutionary Biology

Human-derived alleles in SOST and RUNX2 3'UTRs cause differential regulation in a bone cell-line model

J. Moriano, N. Martinez-Gil, A. Andirko, S. Balcells, D. Grinberg, C. Boeckx

The paper evaluates the functional impact of 3'UTR variants in SOST and RUNX2 from human and Neanderthal/Denisovan lineages in a bone cell-line model, finding differential regulation linked to bone mineral density.

bioRxiv · Apr 21, 2021 · PreprintEvolutionary Biology

A distinct brain expression profile for genes within large introgression deserts and under positive selection in Homo sapiens

R. Buisan, J. Moriano, A. Andirko, C. Boeckx

The paper identifies brain regions with divergent transcriptomic profiles in genes within introgression deserts and under positive selection in humans.

bioRxiv · Mar 26, 2021 · PreprintEvolutionary Biology

Fine-grained temporal mapping of derived high-frequency variants supports the mosaic nature of the evolution of Homo sapiens

A. Andirko, J. Moriano, A. Vitriolo, M. Kuhlwilm, G. Testa, C. Boeckx

The paper temporally maps high-frequency variants in Homo sapiens to support a mosaic evolutionary model, finding bimodal distributions and time-specific gene enrichments.

bioRxiv · Jan 22, 2021 · PreprintEvolutionary Biology

Modern human changes in regulatory regions implicated in cortical development

J. Moriano, C. Boeckx

The paper identifies regulatory regions with modern human-specific SNVs that affect cortical development genes, particularly those involved in chromatin regulation.

bioRxiv · Oct 17, 2019Evolutionary Biology