Author

G. Testa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Vitriolo· 3 shared C. Boeckx· 3 shared C. E. Villa· 3 shared A. Andirko· 2 shared J. Moriano· 2 shared M. Lupia· 2 shared N. Colombo· 2 shared P. Lo riso· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersEvolutionary Biology

A. Vitriolo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A multi-layered integrative analysis reveals a cholesterol metabolic program in outer radial glia with implications for human brain evolution

J. Moriano, O. Leonardi, A. Vitriolo, G. Testa, C. Boeckx

The paper identifies a cholesterol metabolic program in outer radial glia regulated by KLF6 and links it to human brain evolution through integrative analysis of single-cell data and paleogenomic insights.

bioRxiv · Jun 23, 2023Evolutionary Biology

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

R. Angioni, M. Bonfanti, N. Caporale, R. Sanchez-Rodriguez, F. Munari, A. Savino, D. Buratto, I. Pagani, N. Bertoldi, C. Zanon, P. Ferrari, E. Ricciardelli, C. Putaggio, S. Ghezzi, F. Elli, , G. Testa

The paper identifies RAGE as a novel receptor for SARS-CoV-2 that mediates monocyte infection and contributes to COVID-19 severity through single-cell analysis of immune responses.

bioRxiv · May 22, 2022Immunology

Fine-grained temporal mapping of derived high-frequency variants supports the mosaic nature of the evolution of Homo sapiens

A. Andirko, J. Moriano, A. Vitriolo, M. Kuhlwilm, G. Testa, C. Boeckx

The paper temporally maps high-frequency variants in Homo sapiens to support a mosaic evolutionary model, finding bimodal distributions and time-specific gene enrichments.

bioRxiv · Jan 22, 2021 · PreprintEvolutionary Biology

7q11.23 Syndromes Reveal BAZ1B as a Master Regulator of the Modern Human Face and Validate the Self-Domestication Hypothesis

M. Zanella, A. Vitriolo, A. Andirko, P. T. Martins, S. Sturm, T. O'Rourke, M. Laugsch, N. Malerba, A. Skaros, S. Trattaro, P.-L. Germain, G. Merla, A. Rada-Iglesias, C. Boeckx, G. Testa

The paper identifies BAZ1B as a master regulator of the modern human face and validates the self-domestication hypothesis through analysis of 7q11.23 CNVs and paleogenetic data.

bioRxiv · Mar 6, 2019Evolutionary Biology

Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer

T. Velletri, C. E. Villa, M. Lupia, P. Lo riso, R. Luongo, A. Lopez Tobon, M. De Simone, R. J. P. Bonnal, S. Minucci, S. Piccolo, N. Colombo, M. Pagani, U. Cavallaro, G. Testa

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.

bioRxiv · Nov 30, 2018 · PreprintCancer Biology

A cell-of-origin epigenetic tracer reveals clinically distinct subtypes of high grade serous ovarian cancer

P. Lo Riso, C. E. Villa, G. Gasparoni, R. Luongo, A. Manfredi, A. Vingiani, A. Jungmann, A. Garbi, M. Lupia, P. Laise, V. Das, G. Pruneri, G. Viale, N. Colombo, U. Cavallaro, , G. Testa

This study identifies DNA methylation differences between fimbrial and ovarian surface epithelia to create an epigenetic tracer that stratifies high grade serous ovarian cancer into clinically distinct subtypes with prognostic significance.

bioRxiv · Nov 30, 2018Cancer Biology