Cell BiologybioRxiv
A partnership of the lipid scramblase XK and of the lipid transfer protein VPS13A at the plasma membrane
A. Guillen-Samander, Y. Wu, S. S. Pineda…·P. De Camilli
This study shows that VPS13A and XK interact at ER-PM contacts, with VPS13A's PH domain binding XK, and suggests this interaction may link lipid transfer to PM lipid scrambling, potentially contributing to neurodegeneration.
DOI 10.1073/pnas.2205425119