Cancer BiologybioRxivPreprint
Arginine depletion through ADI-PEG20 to treat argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type
J. X. Ji, D. R. Cochrane, B. Tessier-Cloutier…·D. G. Huntsman
This paper identifies ASS1 deficiency in rare ovarian cancers and shows that ADI-PEG20 inhibits tumor growth in ASS1-deficient models.
DOI 10.1101/845586