Recombinant ACE2 Expression is Required for SARS-CoV-2 to Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses
J. Nascimento Conde, W. R. Schutt, E. Gorbunova, E. R. Mackow
This study shows that SARS-CoV-2 cannot directly infect primary human endothelial cells without recombinant ACE2 expression, but infection of ACE2-expressing endothelial cells induces inflammatory and procoagulative responses seen in COVID-19.
bioRxiv · Nov 10, 2020Microbiology