Kinase inhibition of G2019S-LRRK2 restores autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions
J. Obergasteiger, G. Frapporti, G. Lamonaca, S. Pizzi, A. Picard, F. Pischedda, G. Piccoli, E. Lobbestael, V. Baekelandt, A. A. Hicks, C. Corti, P. P. Pramstaller, M. Volta
This study investigates how G2019S-LRRK2 mutation disrupts autophagy-lysosome pathway function and leads to alpha-synuclein accumulation, showing kinase inhibition can restore pathway function and reduce inclusions.
bioRxiv · Jul 20, 2019Cell Biology