Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains
M. Myllykoski, A. Sutinen, M. K. Koski, J. P. Kallio, A. Raasakka, J. Myllyharju, R. K. Wierenga, P. Koivunen
The paper determines the 3D structure of human P4H-TM using X-ray crystallography, revealing structural features and Ca2+ binding properties relevant to its catalytic activity and association with HIDEA syndrome.
bioRxiv · Oct 25, 2020Biochemistry