A. Sutinen

The cytoplasmic tail of myelin protein zero induces morphological changes in lipid membranes

This paper investigates how the cytoplasmic tail of P0 affects lipid membrane morphology and describes the production of full-length P0 for further study.

Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc

This paper characterizes two anti-Arc nanobodies that bind to the ligand-binding pocket of human Arc-NL, revealing their structural and functional properties as competitive inhibitors.

Conformational analysis of membrane-proximal segments of GDAP1 in a lipidic environment using synchrotron radiation suggests a mode of assembly at the mitochondrial outer membrane

This study uses synchrotron radiation and spectroscopy to model GDAP1 assembly at the mitochondrial outer membrane, suggesting a single transmembrane helix flanked by peripheral helices.

Conserved intramolecular networks in GDAP1 are closely connected to CMT-linked mutations and protein stability

This study analyzes GDAP1 mutations linked to CMT, showing they affect protein stability and conserved intramolecular networks, potentially leading to mitochondrial dysfunction and neuronal degeneration.

Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1

This study investigates the structural and biochemical effects of CMT-linked GDAP1 mutations, finding reduced thermal stability and disrupted interaction networks that may impair neuronal function.

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

The paper determines the crystal structure of the human GDAP1 core domain, identifies a fatty acid ligand, and reveals structural insights into disease-related mutations and oligomerization.

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains

The paper determines the 3D structure of human P4H-TM using X-ray crystallography, revealing structural features and Ca2+ binding properties relevant to its catalytic activity and association with HIDEA syndrome.