mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
P. Stavrides, C. N. Goulbourne, J. Peddy, C. Huo, M. Rao, V. Khetarpal, D. M. Marchionini, R. A. Nixon, D.-S. Yang
This study shows that mTOR inhibition in HD model mice improves autophagy and reduces mutant huntingtin accumulation.
eLife · May 20, 2025Peer-reviewedPathology