Identification and Optimization of cell active 4-anilino-quin(az)oline Inhibitors for Protein Kinase Novel 3 (PKN3)
C. R. M. Asquith, L. Temme, T. Laitinen, J. Pickett, F. E. Kwarcinski, P. Sinha, C. I. Wells, G. J. Tizzard, R. Zutshi, D. H. Drewry
The paper identifies 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine as a potent PKN3 inhibitor with an IC50 of 1.3 μM in cells, suggesting its potential as a tool for studying PKN3 biology and therapeutic applications.
bioRxiv · Mar 2, 2020 · PreprintPharmacology & Toxicology