Functional and structural resilience of the active site loop in the evolution of Plasmodium lactate dehydrogenase.
J. D. Wirth, J. I. Boucher, J. R. Jacobowitz, S. Classen, D. Theobald
The study shows PfLDH activity remains resilient to loop perturbations, suggesting alternative insertions could evolve LDH specificity as long as they contain a tryptophan in the correct position.
bioRxiv · Aug 7, 2018Biochemistry